Spatial structure increases the waiting time for cancer

Spatial structure increases the waiting time for cancer.

Cancer results from a sequence of genetic and epigenetic changes which lead to a variety of abnormal phenotypes including increased proliferation and survival of somatic cells, and thus, to a selective advantage of pre-cancerous cells. The notion of cancer progression as an evolutionary process has been experiencing increasing interest in recent years. Many efforts have been made to better unde...

the search for the self in becketts theatre: waiting for godot and endgame

this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...

Public transport fleet scheduling for minimizing total transfer waiting time

Public transportation has been one of the most important research fields in the two last decades. The purpose of this paper is to create a schedule for public transport fleets such as buses and metro trains with the goal of minimizing the total transfer waiting time. We extend previous research works in the field of transit schedule with considering headways of each route as decision variables....

No time for waiting: Statistical structure reflects subjective complexity.

Waiting time models of cancer progression

Cancer progression is an evolutionary process that is driven by mutation and selection in a population of tumor cells. We discuss mathematical models of cancer progression, starting from traditional multistage theory. Each stage is associated with the occurrence of genetic alterations and their fixation in the population. We describe the accumulation of mutations using conjunctive Bayesian netw...